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177 results on '"Meng, Yanyan"'

14. Mulberry Leaf Flavonoids Inhibit Liver Inflammation in Type 2 Diabetes Rats by Regulating TLR4/MyD88/NF-κB Signaling Pathway

Author

Duan, Yuhui, primary, Dai, Hongyu, additional, An, Yongcheng, additional, Cheng, Long, additional, Shi, Lu, additional, Lv, Yinglan, additional, Li, Huimin, additional, Wang, Chen, additional, He, Changhao, additional, Zhang, Huilin, additional, Huang, Yan, additional, Fu, Wanxin, additional, Meng, Yanyan, additional, and Zhao, Baosheng, additional

Published
2022
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17. Rutin‐activated adipose tissue thermogenesis is correlated with increased intestinal short‐chain fatty acid levels

Author

Cheng, Long, primary, Shi, Lu, additional, He, Changhao, additional, Wang, Chen, additional, Lv, Yinglan, additional, Li, Huimin, additional, An, Yongcheng, additional, Dai, Hongyu, additional, Duan, Yuhui, additional, Zhang, Huilin, additional, Huang, Yan, additional, Fu, Wanxin, additional, Meng, Yanyan, additional, and Zhao, Baosheng, additional

Published
2022
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19. Advances in Composite Biofilm Biomimetic Nanodrug Delivery Systems for Cancer Treatment.

Author

Meng, Yanyan, Chen, Shaoqing, Wang, Cheli, and Ni, Xinye

Abstract

Single biofilm biomimetic nanodrug delivery systems based on single cell membranes, such as erythrocytes and cancer cells, have immune evasion ability, good biocompatibility, prolonged blood circulation, and high tumor targeting. Because of the different characteristics and functions of each single cell membrane, more researchers are using various hybrid cell membranes according to their specific needs. This review focuses on several different types of biomimetic nanodrug-delivery systems based on composite biofilms and looks forward to the challenges and possible development directions of biomimetic nanodrug-delivery systems based on composite biofilms to provide reference and ideas for future research. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Robust CoFe2O4@Carbon Nanotube/Polydimethylsiloxane Foams with Low Thermal Conductivity for Electromagnetic Interference Shielding.

Author

Xie, Zhaoxin, Wei, Zijian, Meng, Yanyan, Pan, Na, Zhang, Ran, Zhan, Yanhu, and Xia, Hesheng

Abstract

Multifunctional polymer-based electromagnetic interference (EMI) shielding foams are attracting considerable attention owing to their ability to mitigate increasing electromagnetic-wave pollution. However, developing robust foams with excellent EMI shielding capabilities and superior thermal insulation properties remains challenging. Herein, CoFe2O4@carbon nanotube/polydimethylsiloxane/expandable polymer microsphere (CFO@CPE) foams were successfully prepared using a combination procedure involving solution mixing, freeze-drying, and hot-press molding. The synergistic effect of the porous structure and segregated magnetic/conductive network enabled the CFO@CPE foam to exhibit a shielding effectiveness of 48.85 dB and a low thermal conductivity of 0.106 W/(m·K). In addition, the impact and compressive strengths of the obtained foams reached 3.78 kJ/m2 and 8.17 MPa, respectively. These features support the application of the resultant foam as an EMI shielding material in complex practical situations. [ABSTRACT FROM AUTHOR]

Published
2023
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43. The protease inhibitor E64d improves ox-LDL-induced endothelial dysfunction in human aortic endothelial cells

Author

Chen, Min, Ren, Lina, Meng, Yanyan, Shi, Liye, Chen, Ling, Yu, Bo, Wu, Qianqian, and Qi, Guoxian

Subjects
Atherosclerosis -- Prevention, Endothelium -- Diseases -- Physiological aspects, Protease inhibitors -- Physiological aspects, Cysteine -- Physiological aspects, Biological sciences, Diseases, Prevention, Physiological aspects
Abstract

Oxidized low-density lipoprotein (ox-LDL)-induced endothelial dysfunction in human vascular endothelial cells contributes to the development of atherosclerosis. E64d, a cysteine protease inhibitor, blocks the elastolytic activity of cathepsin essential for vascular matrix remodeling and reduces neurovascular endothelial apoptosis. The objective of this study was to investigate the effects and the underling mechanisms of E64d on ox-LDL-induced endothelial dysfunction in human aortic endothelial cells (HAECs). HAECs were treated with various concentrations of ox-LDL (0-200 mg/L) for 24 h with or without E64d. The results showed that E64d attenuated ox-LDL-induced increase in soluble intercellular adhesion molecule-1 (sICAM-1) concentration and reduction in endothelial nitric oxide synthase (eNOS) expression, prevented ox-LDL-induced reduction in cell viability and migration ability of HAECs. E64d decreased the protein expression of cathepsin B (CTSB), Beclin 1, and microtubuleassociated protein light chain 3 (LC3)-II, but not p62. LC3 puncta and autophagosome formation were also reduced by E64d in HAECs. Moreover, E64d decreased the production of MDA and increased the activity of SOD. The results showed that E64d ameliorated ox-LDL-induced endothelial dysfunction in HAECs. Key words: E64d, endothelial dysfunction, ox-LDL, autophagy, HAECs, atherosclerosis, oxidative stress. Le dysfonctionnement endothelial provoque par les lipoproteines de basse densite oxydees (ox-LDL) dans les cellules endotheliales vasculaires humaines contribue a la formation de l'atherosclerose. L'E64d, un inhibiteur de la cysteine protease, entraine une inhibition de l'activite elastolytique de la cathepsine essentielle au remodelage de la matrice vasculaire et l'attenuation de l'apoptose endotheliale neurovasculaire. Ces travaux avaient comme objectif d'etudier les effets et les modes d'action sous-jacents de l'E64d sur le dysfonctionnement endothelial provoque par les ox-LDL dans des cellules endotheliales d'aortes humaines (ou HAEC Pour << human aortic endothelial cells >>). Nous avons expose les HAEC a diverses concentrations d'ox-LDL (0 a 200 mg/L) pendant 24 h avec ou sans E64d. Les resultats ont montre que l'E64d attenuait l'augmentation des concentrations de molecule 1 d'adherence intercellulaire soluble (ou sICAM-1 pour << soluble intercellular adhesion molecule-1 >>) provoquee par les ox-LDL et la diminution de l'expression de l'oxyde nitrique synthase endotheliale (ou eNOS pour << endothelial nitric oxide synthase >>), prevenait la reduction de la viabilite des cellules provoquee par les ox-LDL et la capacite de migration des HAEC. L'E64d entrainait une diminution de l'expression proteique de cathepsine B (CTSB), de la proteine Becline 1 et de la proteine LC3-II (<< light chain 3 >>) associee aux microtubules, mais pas de la proteine p62. L'E64d entrainait aussi une diminution de la formation d'autophagosomes et de punctas de LC3 dans les HAEC. De plus, l'E64d entrainait une diminution de la production de MDA et une augmentation de l'activite de la SOD. Les resultats ont montre que l'E64d permettait d'attenuer le dysfonctionnement endothelial provoque par les ox-LDL dans les HAEC. [Traduit par la Redaction] Mots-cles: E64d, dysfonctionnement endothelial, ox-LDL, autophagie, HAEC, atherosclerose, stress oxydatif., Introduction Atherosclerosis, the leading cause of death and morbidity worldwide, is a disease characterized by imbalanced lipid metabolism and chronic inflammation (Weber and Noels 2011). Endothelial cells cover the inner [...]

Published
2018
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